Building Better Biomolecules
Peptide Dynamics
Computational Biology, Contract Research and Development, Technical Product Advisory
Our Services
Molecular Dynamics
We offer comprehensive molecular dynamics services, including the development of Structure-Activity Relationship (SAR) models, to help predict molecular interactions, optimize compounds, and enhance product design.
Peptide Discovery and Drug Design
Our computational methods help identify and design new peptides and molecules with therapeutic potential, tailored to your specific needs. Besides our in silico solutions, we can provide extensive expertise for in vitro experiments.
Manufacturing Advisory
We provide expert guidance on selecting and managing third-party manufacturing partners to ensure cost-effective and compliant production processes, tailored to your industry's needs.
Compliance Advisory
We analyze your processes and ensure they meet Good Manufacturing Practice (GMP) standards, help you improve your Quality Management System (QMS) and facilitate regulatory approval for your products.
Use Cases
You wish to improve an existing product:
Step 1
We provide you with an initial in silico assessment based on our computational modelling.
Step 2
We advise, design or run in vitro experiments, depending on equipment and complexity, confirming the modelling-based solution.
Step 3
We assist you in implementing the solution in your existing process, while assessing associated compliance requirements.
Step 4
We provide you with a quality and regulatory compliance assessment, to ensure the solution does not encounter any market access barriers.
You wish to design a peptide from scratch:
Step 1
You have a particular need in terms of biological or chemical functionality.
Step 2
With our modelling expertise, we provide you with one or several potential molecular structures.
Step 3
We select and experimentally validate the best modelling candidates while assessing early compliance barriers.
Step 4
We help you develop and scale the manufacturing of your biomolecule.
Specialty Services
Computational Biology
- Bioinformatics
- Virtual Screening
- Pharmacophore Analysis
- Molecular Docking
- Computer Aided Drug Design
- Molecular Dynamics
- Quantum Mechanics Simulation
- Structure Prediction
- Homology Modeling
- QSAR/SAR
Laboratory Experiments
- Analytical Molecular Assessment (Mass Spectroscopies)
- Biophysical Assessment
- In Vitro Binding
- Cell Culture/Animal Testing (Molecular Assays, Microscopy, Electrophysiology)
Manufacturing and Compliance
- Internal Paper-Based / Virtual Audit
- Inspection readiness
- Quality Management System (QMS)
- HACCP design
- HAZOP study
- Clinical Trial Design
- Computer System Validation
- Lean Six Sigma process improvement
About Us
We are multidisciplinary team of scientists and engineers affiliated to the University of Texas, Medical Branch. Our combined expertise ranges from computational chemistry to laboratory and manufacturing experience.
Prof. Kyle Koss, PhD
As an assistant professor at the University of Texas Medical Branch in the Sealy Institute for Drug Discovery and Department of Neurobiology, Kyle has research experience in chemical engineering, nanotechnology, biomaterials, peptide design and discovery, bioconjugate chemistry, and neural tissue engineering. His research focuses on bioengineering neural immune cells to improve the longevity and interfacial function of implanted circuitry (brain computer interfaces), and sugar binding peptides (hyaluronic acid and DNA/RNA). He holds several provisional and non-provisional patents in these fields.
Alejandro Rodriguez, MSc, MBA
With over 10 years of experience in R&D, manufacturing, quality, regulatory affairs, and business development, Alejandro brings a versatile profile to Peptide Dynamics. A chemical engineering and biotechnology graduate from École Polytechnique Fédérale de Lausanne (EPFL), he has worked at national research institutes and Fortune 500 companies in the biotechnology, food, and pharmaceutical sectors. Alejandro's roles have ranged from subject matter expert to management, showcasing his ability to excel in various capacities.
Jordan Beck
Jordan is a computational biologist who has applied his unique molecular dynamics workflows co-authoring studies in pharmacology, biomedical research, bioengineering, organometallic chemistry, membrane dynamics, tissue engineering, and more. He has delved into the cutting edge of his profession, from robotics, organoid culture, to developing machine learning software tools. Jordan's varied repertoire is efficacious in even the most niche scientific undertakings.
A Network of Experts
We work and partner with a variety of European and North-American individual experts, institutions and companies, affiliated to and including: University of Texas, Medical Branch (UTMB) Swiss ETH Domain (EPFL, ETHZ and their research centers), top-tier electrophysiologists, biologists, biochemists, analytical and organic chemists, former regulatory agency inspectors, compliance and regulatory experts, contract manufacturers of cosmetic, food and pharma products.
Some of our peptide-related inventions and publications
-
Cosmetic Hyaluronic Acid Binding Peptides
(University of Arizona Link)
The invention focuses on developing a novel gel technology aimed at rejuvenating aging skin by targeting hyaluronic acid (HA) receptors. -
Heparin conjugated to collagen-binding peptides for targeting to biological and synthetic tissues
(US Patent US12036234B2)
We showed that heparin conjugated with collagen binding peptides were able to localize in vascular injury cites and reduce clotting and neointimal hyperplasia. The molecules could be used in MRI detection and conjugated with multivalent branched peptides to enhance binding. -
Methods and compositions for localization of growth factors
(US Patent US20240245791A1)
We showed that vascular growth factors (VEGF and ANG1) could be conjugated to collagen binding peptides, bind to collagen substrates and activate growth factor receptors. We also generated co-assembling bioconjugates with biotin and avidin capable of forming macromolecular layers on collagen. -
A class of peptides designed to replicate and enhance the Receptor for Hyaluronic Acid Mediated Motility binding domain
(PubMed Link)
We showed that helical peptides designed with spatially arranged BX7B binding domains, presented in a helical net, could effectively bind to hyaluronic acid. -
Toward discovering a novel family of peptides targeting neuroinflammatory states of brain microglia and astrocytes
(PubMed Link)
We showed that several peptides could exclusively bind to neuroinflammatory phenotypes of brain cells microglia and astrocytes, and also indentified their potential origin proteins.